Description
Eotaxin-2, also known as MPIF-2 and CCL24, is a member of the CC chemokine family. It interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils and the release of histamine and leukotriene C4 from basophils primed with IL-3 (1). This chemokine is also strongly chemotactic for resting T lymphocytes and slightly chemotatic for neutrophils (2). Murine Eotaxin-2 appears to be produced constitutively in the jejunum and spleen. Production is induced by allergen challenge and IL-4 overexpression (3). LPS and IL-4 also differentially regulate the expression of Eotaxin-2 in monocytes and macrophages. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells (4). Functionally, Eotaxin-2 is most closely related to Eotaxin/CCL11 and Eotaxin-3/CCL26